Cubilin
Lua error in Module:Infobox_gene at line 53: attempt to index field 'wikibase' (a nil value). Cubilin is a protein that in humans is encoded by the CUBN gene.[1][2][3] It is present upon the luminal surface of enterocytes of the ileum where it facilitates absorption of vitamin B12 by acting as a receptor for IF-cobalamin (intrinsic factor - vitamin B12) complexes, enabling endocytosis of complexes by means of amnionless (AMN).[4][5]
Biochemistry
[edit | edit source]Cubilinis essentially only present in the small intestine and kidneys.[6]
A complex of amnionless and cubilin forms the cubam receptor.[citation needed]
Clinical significance
[edit | edit source]Mutations in CUBN may play a role in autosomal recessive megaloblastic anemia.[3]
Cubilin is a potential diagnostic and prognostic cancer biomarker for kidney cancer.[7] Based on patient survival data, high levels of cubilin in tumor cells is a favourable prognostic biomarker in renal cell carcinoma.[8][9]
References
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Further reading
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