Amnionless
Lua error in Module:Infobox_gene at line 53: attempt to index field 'wikibase' (a nil value). Amnionless is a protein that in humans is encoded by the AMN gene.[1][2]
Function
[edit | edit source]A complex of amnionless and cubilin forms the cubam receptor.
The protein encoded by this gene is a type I transmembrane protein. It is thought to modulate bone morphogenetic protein (BMP) receptor function by serving as an accessory or coreceptor, and thus facilitates or hinders BMP binding. It is known that the mouse AMN gene is expressed in the extraembryonic visceral endoderm layer during gastrulation, but it is found to be mutated in amnionless mouse. The encoded protein has sequence similarity to short gastrulation (Sog) and procollagen IIA proteins in Drosophila.[2]
Clinical significance
[edit | edit source]Mutations of the AMN gene may cause Imerslund–Gräsbeck syndrome.
References
[edit | edit source]External links
[edit | edit source]- Human AMN genome location and AMN gene details page in the UCSC Genome Browser.
Further reading
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