CHAF1B
Lua error in Module:Infobox_gene at line 53: attempt to index field 'wikibase' (a nil value). Chromatin assembly factor 1 subunit B is a protein that in humans is encoded by the CHAF1B gene.[1][2][3]
Function
[edit | edit source]Chromatin assembly factor I (CAF-1) is required for the assembly of histone octamers onto newly-replicated DNA. CAF-I is composed of three protein subunits, p50, p60, and p150. The protein encoded by this gene corresponds to the p60 subunit and is required for chromatin assembly after replication. The encoded protein is differentially phosphorylated in a cell cycle-dependent manner. In addition, it is normally found in the nucleus except during mitosis, when it is released into the cytoplasm. This protein is a member of the WD-repeat HIR1 family and may also be involved in DNA repair.[3]
Interactions
[edit | edit source]CHAF1B has been shown to interact with:
References
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Further reading
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External links
[edit | edit source]- Human CHAF1B genome location and CHAF1B gene details page in the UCSC Genome Browser.
- Human MPP7 genome location and MPP7 gene details page in the UCSC Genome Browser.
