CDH8
Lua error in Module:Infobox_gene at line 53: attempt to index field 'wikibase' (a nil value). Cadherin-8 is a protein that in humans is encoded by the CDH8 gene.[1][2][3]
Function
[edit | edit source]This gene encodes a type II classical cadherin from the cadherin superfamily, integral membrane proteins that mediate calcium-dependent cell-cell adhesion. Mature cadherin proteins are composed of a large N-terminal extracellular domain, a single membrane-spanning domain, and a small, highly conserved C-terminal cytoplasmic domain. The extracellular domain consists of 5 subdomains, each containing a cadherin motif, and appears to determine the specificity of the protein's homophilic cell adhesion activity. Type II (atypical) cadherins are defined based on their lack of a HAV cell adhesion recognition sequence specific to type I cadherins. This particular cadherin is expressed in brain and is putatively involved in synaptic adhesion, axon outgrowth and guidance.[3]
Clinical significance
[edit | edit source]Disruptions of CDH8 in humans have been implicated in autism.[4][5]
References
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Further reading
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External links
[edit | edit source]- CDH8 human gene location in the UCSC Genome Browser.
- CDH8 human gene details in the UCSC Genome Browser.
- Overview of all the structural information available in the PDB for UniProt: P97291 (Mouse Cadherin-8) at the PDBe-KB.
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