CDH11
Lua error in Module:Infobox_gene at line 53: attempt to index field 'wikibase' (a nil value). Cadherin-11 is a protein that in humans is encoded by the CDH11 gene.[1][2]
Function
[edit | edit source]This gene encodes a type II classical cadherin from the cadherin superfamily, integral membrane proteins that mediate calcium-dependent cell-cell adhesion. Mature cadherin proteins are composed of a large N-terminal extracellular domain, a single membrane-spanning domain, and a small, highly conserved C-terminal cytoplasmic domain. Type II (atypical) cadherins are defined based on their lack of a HAV cell adhesion recognition sequence specific to type I cadherins. Expression of this particular cadherin in osteoblastic cell lines, and its upregulation during differentiation, suggests a specific function in bone development and maintenance.[2] The mammalian CDH-11 homologues are termed calsyntenin.[3]
Relevance to cancer
[edit | edit source]CDH11 is overexpressed in 15% of breast cancers and seems essential to tumour progression in some other cancer types.[4][5]
Drug interactions
[edit | edit source]Arthritis drug celecoxib binds to CDH11.[4][5]
Interactions
[edit | edit source]CDH11 has been shown to interact with CDH2.[6]
References
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Further reading
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External links
[edit | edit source]- CDH11 human gene location in the UCSC Genome Browser.
- CDH11 human gene details in the UCSC Genome Browser.
