C1D
Lua error in Module:Infobox_gene at line 53: attempt to index field 'wikibase' (a nil value). Nuclear nucleic acid-binding protein C1D is a protein that in humans is encoded by the C1D gene.[1][2][3][4][5][6] The C1D protein is encoded by a DNA binding gene traced in the nucleus.[7] Protein C1D has a chromosomal location of 2p14.[8] C1D has a family of proteins consisting of C1D homologues which may include Sas10 domains.[9] C1D is thought to bind to RNA and DNA where it may be involved in mechanisms of DNA repair.[9] Protein C1D is ubiquitously expressed in different human tissues.[10]
Function
[edit | edit source]Despite inducing denaturing conditions, C1D shows high-affinity binding to DNA.[9] C1D has demonstrated capability to bind to DNA in DNA repair pathways.[9]
The protein encoded by this gene is a DNA binding and apoptosis-inducing protein and is localized in the nucleus. It is also a Rac3-interacting protein which acts as a corepressor for the thyroid hormone receptor. This protein is thought to regulate TRAX/Translin complex formation. Protein C1D may have a protective effect against relation to the TRAX/Translin complex formation of DNA.[9] Several alternatively spliced transcript variants of this gene have been described, but the full length nature of some of these variants has not been determined.[6]
Interactions
[edit | edit source]C1D has been shown to interact with TSNAX[4] and DNA-PKcs.[11] C1D has also shown to interact notably in mammalian cells and yeast.[12] Interaction in mammalian cells only occur ensuing gamma-irradiation.[12]
Protein expression
[edit | edit source]The protein C1D is thought to be expressed ubiquitously.[10] It may be expressed in high levels in the mammary gland, thyroid gland, salivary gland, medulla oblongata, and hippocampus.[10] It may be expressed at lower levels in the appendix, heart, lungs, skeletal muscles, and colon.[10]
References
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Further reading
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External links
[edit | edit source]- Human C1D genome location and C1D gene details page in the UCSC Genome Browser.
- Human LRP1 genome location and LRP1 gene details page in the UCSC Genome Browser.
