Translin-associated factor X
Lua error in Module:Infobox_gene at line 53: attempt to index field 'wikibase' (a nil value). Translin-associated protein X (abbr. TSNAX or TRAX) is a protein that in humans is encoded by the TSNAX gene.[1][2]
Function
[edit | edit source]This gene encodes a protein which specifically interacts with translin, a DNA-binding protein that binds consensus sequences at breakpoint junctions of chromosomal translocations. The encoded protein contains bipartite nuclear targeting sequences that may provide nuclear transport for translin, which lacks any nuclear targeting motifs.[2] Both TSNAX and translin form the C3PO complex which facilitates endonucleolytic cleavage of the passenger strand during microRNA loading into the RNA-induced silencing complex (RISC).[3]
Interactions
[edit | edit source]TSNAX has been shown to interact with C1D.[4]
References
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Further reading
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External links
[edit | edit source]- Overview of all the structural information available in the PDB for UniProt: Q99598 (Translin-associated protein X) at the PDBe-KB.
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