BD1060

BD1060

Identifiers
IUPAC name N-[2-(3,4-dichlorophenyl)ethyl]-1-pyrrolidineethanamine
CAS Number	138356-10-2
PubChem CID	9882367
ChemSpider	8058042
E number	{{#property:P628}}
CompTox Dashboard (EPA)	{{#property:P3117}}
ECHA InfoCard	{{#property:P2566}}
Chemical and physical data
Formula	C14H20Cl2N2
Molar mass	287.23 g·mol−1
3D model (JSmol)	Interactive image
SMILES C1CCN(C1)CCNCCC2=CC(=C(C=C2)Cl)Cl
InChI InChI=1S/C14H20Cl2N2/c15-13-4-3-12(11-14(13)16)5-6-17-7-10-18-8-1-2-9-18/h3-4,11,17H,1-2,5-10H2 Key:KFLJZQLENAVFAL-UHFFFAOYSA-N

BD1060 or N-[2-(3,4-dichlorophenyl)ethyl]-1-pyrrolidineethanamine is a selective sigma receptor antagonist, with a reported binding affinity of K_i = 3 ± 0.1 nM for the sigma-1 receptor and greater than 50 times selectivity over the sigma-2 receptor.

Like other sigma receptor antagonists, pretreating Swiss Webster mice with BD1060 significantly reduces the behavioral toxicity of cocaine.

See also

• BD1008
• BD1031
• LR132