LR132

LR132

File:LR132.png
Identifiers
IUPAC name (+)-3,4-dichloro-N-[(1R,2S)-2-(1-pyrrolidinyl)cyclohexyl]benzeneethanamine
CAS Number	135211-15-3 checkY
PubChem CID	5471948
ChemSpider	4581994
UNII	K7C7XKK3P3
ChEMBL	ChEMBL320828
E number	{{#property:P628}}
CompTox Dashboard (EPA)	{{#property:P3117}}
ECHA InfoCard	{{#property:P2566}}
Chemical and physical data
Formula	C18H26Cl2N2
Molar mass	341.32 g·mol−1
3D model (JSmol)	Interactive image
SMILES c1cc(c(cc1CCN[C@H]2CCCC[C@H]2N3CCCC3)Cl)Cl
InChI InChI=1S/C18H26Cl2N2/c19-15-8-7-14(13-16(15)20)9-10-21-17-5-1-2-6-18(17)22-11-3-4-12-22/h7-8,13,17-18,21H,1-6,9-12H2/t17-,18+/m0/s1 Key:NREHOBGKKWFKES-ZWKOTPCHSA-N

LR132 or (+)-3,4-dichloro-N-[(1R,2S)-2-(1-pyrrolidinyl)cyclohexyl]benzeneethanamine is a selective sigma receptor antagonist, with a reported binding affinity of K_i = 2 ± 0.1 nM for the sigma-1 receptor and more than 350 times selectivity over the sigma-2 receptor.

Consistent with other reported sigma receptor antagonists, pretreating Swiss Webster mice with LR132 significantly decreases the convulsivity and lethality of cocaine.

See also

• BD1008
• BD1031