Fenoverine

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Fenoverine
File:Fenoverine.svg
Clinical data
AHFS/Drugs.comInternational Drug Names
ATC code
Identifiers
  • 2-[4-(Benzo[d][1,3]dioxol-5-ylmethyl)piperazin-1-yl]-1-(10H-phenothiazin-10-yl)ethanone
CAS Number
PubChem CID
ChemSpider
UNII
KEGG
ChEMBL
E number{{#property:P628}}
CompTox Dashboard (EPA)
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Chemical and physical data
FormulaC26H15N3O3S
Molar mass449.48 g·mol−1
3D model (JSmol)
  • C1CN(CCN1CC2=CC3=C(C=C2)OCO3)CC(=O)N4C5=CC=CC=C5SC6=CC=CC=C64
  • InChI=1S/C26H25N3O3S/c30-26(29-20-5-1-3-7-24(20)33-25-8-4-2-6-21(25)29)17-28-13-11-27(12-14-28)16-19-9-10-22-23(15-19)32-18-31-22/h1-10,15H,11-14,16-18H2
  • Key:UBAJTZKNDCEGKL-UHFFFAOYSA-N
  (verify)

Fenoverine (INN) is an antispasmodic [also known as spasmolytics] drug,[1] which acts by inhibiting calcium channels[2] [much in the same way as traditional calcium channel blockers, which are used as antianginal drugs]. In the case of Fenoverine, the relaxation occurs in abdominal / intestinal smooth muscles, while in case of antianginal drugs, the relaxation occurs in coronary vessels. Notably Fenoverine does not act as an antianginal agent.

Toxicity

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Fenoverine is known to cause rhabdomyolysis.[2][3]

References

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