ARFGEF2
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Lua error in Module:Infobox_gene at line 53: attempt to index field 'wikibase' (a nil value). Brefeldin A-inhibited guanine nucleotide-exchange protein 2 is a protein that in humans is encoded by the ARFGEF2 gene.[1][2]
Function
[edit | edit source]ADP-ribosylation factors (ARFs) play an important role in intracellular vesicular trafficking. The protein encoded by this gene is involved in the activation of ARFs by accelerating replacement of bound GDP with GTP and is involved in Golgi transport. It contains a Sec7 domain, which may be responsible for its guanine-nucleotide exchange activity and also brefeldin A inhibition.[2]
Interactions
[edit | edit source]ARFGEF2 has been shown to interact with ARFGEF1,[3] PRKAR1A[4] and PRKAR2A.[4]
References
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External links
[edit | edit source]- Human ARFGEF2 genome location and ARFGEF2 gene details page in the UCSC Genome Browser.
Further reading
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