ARFGEF1
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Lua error in Module:Infobox_gene at line 53: attempt to index field 'wikibase' (a nil value). Brefeldin A-inhibited guanine nucleotide-exchange protein 1 is a protein that in humans is encoded by the ARFGEF1 gene.[1][2][3]
Function
[edit | edit source]ADP-ribosylation factors (ARFs) play an important role in intracellular vesicular trafficking. The protein encoded by this gene is involved in the activation of ARFs by accelerating replacement of bound GDP with GTP. It contains a Sec7 domain, which may be responsible for the guanine-nucleotide exchange activity and also the brefeldin A inhibition.[3]
Interactions
[edit | edit source]ARFGEF1 has been shown to interact with FKBP2,[4] ARFGEF2[5] and PRKAR1A.[6]
References
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External links
[edit | edit source]- Human ARFGEF1 genome location and ARFGEF1 gene details page in the UCSC Genome Browser.
Further reading
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