ABCC4

ATP-binding cassette sub-family C member 4 (ABCC4), also known as the multidrug resistance-associated protein 4 (MRP4) or multi-specific organic anion transporter B (MOAT-B), is a protein that in humans is encoded by the ABCC4 gene.

ABCC4 acts as a regulator of intracellular cyclic nucleotide levels and as a mediator of cAMP-dependent signal transduction to the nucleus. MRP4/ABCC4 also transports prostaglandins, for example PGE2, out of the cell where they can bind receptors.

MRP4/ABCC4 expression is dysregulated in several cancers and is also upregulated in peritoneal endometriosis.

Interactive pathway map

Click on genes, proteins and metabolites below to link to respective articles.

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Fluorouracil (5-FU) Activity edit

See also

• ATP-binding cassette transporter

External links

• ABCC4+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
• Human ABCC4 genome location and ABCC4 gene details page in the UCSC Genome Browser.