ABCC3

Canalicular multispecific organic anion transporter 2 is a protein that in humans is encoded by the ABCC3 gene.

Function

The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. The specific function of this protein has not yet been determined; however, this protein may play a role in the transport of biliary and intestinal excretion of organic anions. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized.

ABCC3 is induced as a hepatoprotective response to a variety of pathologic liver conditions. The constitutive androstane receptor, pregnane X receptor and nuclear factor (erythroid-derived 2)-like 2 (Nrf2) transcription factors are involved in mediating induction. A functional antioxidant response element in the 8th intron of the human ABCC3 gene appears responsible for Nrf2-mediated induction in response to oxidative stress.

Interactive pathway map

Click on genes, proteins and metabolites below to link to respective articles.

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Fluorouracil (5-FU) Activity edit

See also

• ATP-binding cassette transporter

External links

• ABCC3+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
• Human ABCC3 genome location and ABCC3 gene details page in the UCSC Genome Browser.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.