XCT-790

XCT-790

File:XCT790-A.png
Names
Preferred IUPAC name (2E)-3-(4-{[2,4-Bis(trifluoromethyl)phenyl]methoxy}-3-methoxyphenyl)-2-cyano-N-[5-(trifluoromethyl)-1,3,4-thiadiazol-2-yl]prop-2-enamide
Identifiers
CAS Number	796844-24-1 checkY 725247-18-7 (non-specific) checkY
3D model (JSmol)	Interactive image
ChEMBL	ChEMBL189753 ☒N
ChemSpider	5293979 ☒N
ECHA InfoCard
E number
IUPHAR/BPS	2832
PubChem CID	6918788
UNII	A4CE428LGJ checkY
CompTox Dashboard (EPA)	{{#property:P3117}}
InChI InChI=1S/C23H13F9N4O3S/c1-38-17-7-11(6-13(9-33)18(37)34-20-36-35-19(40-20)23(30,31)32)2-5-16(17)39-10-12-3-4-14(21(24,25)26)8-15(12)22(27,28)29/h2-8H,10H2,1H3,(H,34,36,37)/b13-6+ ☒N Key: HQFNFOOGGLSBBT-AWNIVKPZSA-N ☒N InChI=1/C23H13F9N4O3S/c1-38-17-7-11(6-13(9-33)18(37)34-20-36-35-19(40-20)23(30,31)32)2-5-16(17)39-10-12-3-4-14(21(24,25)26)8-15(12)22(27,28)29/h2-8H,10H2,1H3,(H,34,36,37)/b13-6+ Key: HQFNFOOGGLSBBT-AWNIVKPZBQ
SMILES COC1=C(C=CC(=C1)/C=C(\C#N)/C(=O)NC2=NN=C(S2)C(F)(F)F)OCC3=C(C=C(C=C3)C(F)(F)F)C(F)(F)F
Properties
Chemical formula	C23H13F9N4O3S
Molar mass	596.424949
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). ☒N verify (what is checkY☒N ?) Infobox references

XCT-790 is a potent and selective inverse agonist ligand of the estrogen-related receptor alpha (ERRα). Independent of its inhibition of ERRα, XCT-790 is a potent mitochondrial electron transport chain uncoupler.

Mitochondrial electron transport chain uncoupling effect

XCT-790 has been shown to uncouple oxygen consumption from ATP production in mitochondria at very low, nanomolar-range doses independently of ERRα expression. Its effects are similar to proton ionophores such as FCCP, which disrupt mitochondrial transmembrane electrochemical gradients. This uncoupling leads to a fast drop in ATP production and, consequently, a prompt activation of AMPK.

External links

• XCT790 at the U.S. National Library of Medicine Medical Subject Headings (MeSH)