WDR83
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WD repeat domain 83 is a protein that in humans is encoded by the WDR83 gene. [1]
Function
[edit | edit source]This gene encodes a member of the WD-40 protein family. The protein is proposed to function as a molecular scaffold for various multimeric protein complexes. The protein associates with several components of the extracellular signal-regulated kinase (ERK) pathway, and promotes ERK activity in response to serum or other signals. The protein also interacts with egl nine homolog 3 (EGLN3, also known as PHD3) and regulates expression of hypoxia-inducible factor 1, and has been purified as part of the spliceosome. Alternative splicing results in multiple transcript variants.
References
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Further reading
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This article incorporates text from the United States National Library of Medicine, which is in the public domain.