WDR5
Lua error in Module:Infobox_gene at line 53: attempt to index field 'wikibase' (a nil value). WD repeat-containing protein 5 is a protein that in humans is encoded by the WDR5 gene.[1][2]
This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. This protein contains 7 WD repeats. Alternatively spliced transcript variants encoding the same protein have been identified.[2]
Interactions
[edit | edit source]WDR5 has been shown to interact with Host cell factor C1[3][4] and MLL.[3] It also interacts with the long non-coding RNA HOTTIP and to the lncRNA NeST.[5][6] WDR5 is a key determinant for MYC recruitment to chromatin[7]
References
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Further reading
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