VAV2
Lua error in Module:Infobox_gene at line 53: attempt to index field 'wikibase' (a nil value). Guanine nucleotide exchange factor VAV2 is a protein that in humans is encoded by the VAV2 gene.[1][2]
VAV2 is the second member of the VAV oncogene family. Unlike VAV1, which is expressed exclusively in hematopoietic cells, VAV2 transcripts were found in most tissues.[2]
Interactions
[edit | edit source]VAV2 is a GEF for RAC1, specifically in fibroblasts VAV2 is necessary for integrin, but not growth factor–dependent activation of RAC leading to lamellipodia formation.[3] Double DH domain mutations, L342R/L343SVav2 function as a dominant negative, blocking VAV2 GEF activity for RAC1[3] and a PH domain mutant is required for recruitment of VAV2 to the membrane in order to elicit GEF activity.[3] VAV2 has also been shown to regulate collagen phagocytosis in a RAC1-dependent manner[4] and interact with CD19[5] and Grb2.[6][7]
References
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Further reading
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External links
[edit | edit source]- Overview of all the structural information available in the PDB for UniProt: P52735 (Guanine nucleotide exchange factor VAV2) at the PDBe-KB.
