UVRAG
Lua error in Module:Infobox_gene at line 53: attempt to index field 'wikibase' (a nil value). UV radiation resistance-associated gene protein is a protein that in humans is encoded by the UVRAG gene.[1][2]
This gene complements the ultraviolet sensitivity of xeroderma pigmentosum group C cells and encodes a protein with a C2 domain. The protein activates the Beclin1-PI(3)KC3 complex, promoting autophagy and suppressing the proliferation and tumorigenicity of human colon cancer cells.
Chromosomal aberrations involving this gene are associated with left-right axis malformation and mutations in this gene have been associated with colon cancer.[2]
References
[edit | edit source]Further reading
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