USP14
Lua error in Module:Infobox_gene at line 53: attempt to index field 'wikibase' (a nil value). Ubiquitin-specific protease 14 is an enzyme that in humans is encoded by the USP14 gene.[1][2]
This gene encodes a member of the ubiquitin-specific processing (UBP) family of proteases that is a deubiquitinating enzyme (DUB) with His and Cys domains. This protein is located in the cytoplasm and cleaves the ubiquitin moiety from ubiquitin-fused precursors and ubiquitinylated proteins. Mice with a mutation that results in reduced expression of the ortholog of this protein are retarded for growth, develop severe tremors by 2 to 3 weeks of age followed by hindlimb paralysis and death by 6 to 10 weeks of age. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.[2]
Interactions
[edit | edit source]USP14 has been shown to interact with CXCR4.[3]
Inhibitors
[edit | edit source]- IU1 and related compounds [4][5]
- VLX1570 (non selective inhibitor of proteasome deubiquitinases)
- Degrasyn (WP1130) (non selective deubiquitinase inhibitor acting at USP9, USP5, USP14, and UCH37)
References
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Further reading
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External links
[edit | edit source]- Overview of all the structural information available in the PDB for UniProt: P54578 (Ubiquitin carboxyl-terminal hydrolase 14) at the PDBe-KB.
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