UBR5
Lua error in Module:Infobox_gene at line 53: attempt to index field 'wikibase' (a nil value). E3 ubiquitin-protein ligase UBR5 is an enzyme that in humans is encoded by the UBR5 gene.[1][2][3]
Function
[edit | edit source]This gene encodes a progestin-induced protein, which belongs to the HECT (homology to E6-AP carboxyl terminus) family. The HECT family proteins function as E3 ubiquitin-protein ligases, targeting specific proteins for ubiquitin-mediated proteolysis. This gene is localized to chromosome 8q22 which is disrupted in a variety of cancers. This gene potentially has a role in regulation of cell proliferation or differentiation.[3]
Mutations in UBR5 have been associated with autism spectrum disorder.[4][5]
Interactions
[edit | edit source]UBR5 has been shown to interact with:
References
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Further reading
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PDB gallery | |
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External links
[edit | edit source]- Ubr5 : Protein Overview : UCSD-Nature Molecule Pages Archived 2009-01-06 at the Wayback Machine
- Overview of all the structural information available in the PDB for UniProt: O95071 (E3 ubiquitin-protein ligase UBR5) at the PDBe-KB.
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