Tideglusib
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| File:Tideglusib2DACS.svg | |
| File:Tideglusib-ball-and-stick-model.png | |
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| E number | {{#property:P628}} |
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| ECHA InfoCard | {{#property:P2566}}Lua error in Module:EditAtWikidata at line 29: attempt to index field 'wikibase' (a nil value). |
| Chemical and physical data | |
| Formula | C19H14N2O2S |
| Molar mass | 334.39 g·mol−1 |
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Tideglusib (NP-12, NP031112) is a potent and irreversible[1] small molecule glycogen synthase kinase 3 (GSK-3) inhibitor.[2]
Clinical trials
[edit | edit source]Tideglusib has been evaluated in clinical trials for:
- Alzheimer's disease and progressive supranuclear palsy. Both clinical trials were discontinued in 2011 (PSP) and 2012 (Alzheimer's disease) due to lack of efficacy[3][4][5][6][1]
- Congenital/juvenile-onset myotonic muscular dystrophy type I.[7]
Research
[edit | edit source]Tideglusib is or has been under investigation for multiple applications:
- Tooth repair mechanisms that promotes dentine reinforcement of a sponge structure until the sponge biodegrades, leaving a solid dentine structure. In 2016, the results of animal studies were reported in which 0.14 mm holes in mouse teeth were permanently filled.[8][9]
- Preclinical in vitro studies were carried out for neuroblastoma and ovarian cancer with significant ROS-induced apoptosis.[10][11]
- Arrhythmogenic Right Ventricular Cardiomyopathy as of 2025.[12]
References
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- ^ https://www.phri.ca/research/target-2/
