TSPAN32
Lua error in Module:Infobox_gene at line 53: attempt to index field 'wikibase' (a nil value). Tetraspanin-32 is a protein that in humans is encoded by the TSPAN32 gene.[1][2][3]
Function
[edit | edit source]This gene is described as a member of the tetraspanin superfamily whose expression is confined to hematopoietic tissues.[3]
Clinical significance
[edit | edit source]This gene is one of several tumor-suppressing subtransferable fragments located in the imprinted gene domain of 11p15.5, an important tumor suppressor gene region. Alterations in this region have been associated with the Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocortical carcinoma, and lung, ovarian, and breast cancer. This gene is located among several imprinted genes; however, this gene, as well as the tumor-suppressing subchromosomal transferable fragment 4 (TSSC4), escapes imprinting. This gene may play a role in malignancies and disease that involve this region as well as hematopoietic cell function.[3]
References
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Further reading
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External links
[edit | edit source]- TSPAN32 human gene location in the UCSC Genome Browser.
- TSPAN32 human gene details in the UCSC Genome Browser.
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