TMUB2
Lua error in Module:Infobox_gene at line 53: attempt to index field 'wikibase' (a nil value). Transmembrane and ubiquitin-like domain-containing protein 2 is a protein that in humans is encoded by the TMUB2 gene.[1][2][3]
Gene
[edit | edit source]TMUB2 maps on the human chromosome 17, at locus 17q21.31.[3] TMUB2 sits between two neighboring genes, ASB16-AS1 to the left and ATXN7L3 to the right.[4] TMUB2 is 4.99Kb long. The TMUB2 gene can be transcribed into three possible mRNA variants.[5]
Expression
[edit | edit source]TMUB2 is likely ubiquitously expressed throughout the human body.[6] It has a high expression level that is 2.9 times higher than other human genes.[7][8]
Protein
[edit | edit source]The TMUB2 protein has a function that is not currently known. It consists of a 321 amino acid long chain in humans. The human protein has a molecular weight of 33.8kdal, an isoelectric point of 4.73899, and three transmembrane regions.[9] These will likely vary in orthologs.
Homology
[edit | edit source]Paralogs
[edit | edit source]TMUB1 is the only paralog of TMUB2.[10][11] These proteins share a 38% identity and 51% similarity.[12]
Orthologs
[edit | edit source]The table below presents a selection of some of the TMUB2 orthologs to display protein diversity among species.[12]
| Species | Common name | Accession number | Sequence length (aa) | Sequence identity | Sequence similarity |
|---|---|---|---|---|---|
| Pan troglodytes | Chimpanzee | XP_003953053.1 | 301 | 100% | 100% |
| Felis Catus | Cat | XP_003997025.1 | 322 | 95% | 95% |
| Mus Musculus | Mouse | AAH29841.2 | 319 | 85% | 88% |
| Alligator Mississippiensus | Alligator | XP_006271613.1 | 306 | 61% | 71% |
| Haliaeetus leucocephalus | Bald Eagle | XP_010559728 | 301 | 59% | 70% |
| Danio rerio | Zebrafish | NP_001005573.1 | 291 | 47% | 60% |
| Acromyrmex echinatior | Ant | XP_011049429.1 | 354 | 23% | 42% |
| Nannochloropsis Gaditana* | Algae | EWM26843.1 | 476 | 41% | 54% |
| Coccidioides immitis RS* | Pathogenic Fungus | XP_001242306.1 | 418 | 38% | 50% |
*Limited Query Coverage
Protein Interactions
[edit | edit source]In humans, Ubiquitin C (UBC) is a protein with a known interaction with TMUB2.[13][14][15][16] Other proposed interactions include BCL2L13 (BCL2-like 13),[17] SGTA (Small glutamine-rich tetratricopeptide repeat-containing protein),[17] and UBQLN1 (Ubiquilin-1).[17][18][19]
References
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- ^ a b Lua error in Module:Citation/CS1/Configuration at line 2172: attempt to index field '?' (a nil value).
- ^ UCSC Genome Browser: BLAT Search
- ^ NCBI Gene: TMUB2
- ^ EST Profile Viewer: Human[dead link]
- ^ Aceview: TMUB2
- ^ NCBI GEO Profiles
- ^ SDSC Biology Workbench 2.0
- ^ GeneCards: TMUB2
- ^ NCBI Gene: TMUB1
- ^ a b NCBI BLAST: Basic Local Alignment Search Tool
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- ^ a b c Lua error in Module:Citation/CS1/Configuration at line 2172: attempt to index field '?' (a nil value).
- ^ STRING: Functional Protein Association Networks
- ^ BioGRID Database
Further reading
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