TMEM51
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Transmembrane protein 51 is a protein in humans that is encoded by the TMEM51 gene.[1] It is located on the first chromosome (1p36.21) and has 6 isoforms in humans.[2] It has orthologs in mammals, birds, reptiles, amphibians, and fish.[2]
It is predicted to be a transmembrane protein due to the transmembrane regions within its coding sequence.[3]
TMEM51-AS1 (a long non-coding RNA from the TMEM51 locus) acts as a tumor suppressor when overexpressed, inhibiting cancer cell progression.[4] Mutations or polymorphisms of the TMEM51 are associated susceptibility to Reynaud's syndrome.[5]
References
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