TMBIM4
Lua error in Module:Infobox_gene at line 53: attempt to index field 'wikibase' (a nil value). Transmembrane BAX inhibitor motif-containing protein 4 is a protein that in humans is encoded by the TMBIM4 gene.[1][2][3] It is also known as human Golgi anti-apoptotic protein (hGAAP) due to its function and sub-cellular localization.
Function
[edit | edit source]Human GAAP [4] is a protein present in the Golgi that helps regulate apoptosis, a form of programmed cell death. By regulating the fluxes of Ca+2, an increase of GAAP can help prevent apoptosis.[5][6] GAAP is also involved in promoting cell migration[7][8] and has been identified as a novel Golgi cation channel.[9] Other GAAPs can be found in all eucaryotes analyzed and in some bacteria. A viral GAAP (vGAAP) can also be found in some strains of vaccinia virus, the live vaccine used to eradicate smallpox.
See also
[edit | edit source]- Golgi
- Apoptosis
- Ion channel
- Cell migration
References
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Further reading
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