TM5441

TM5441
Clinical data
ATC code	None;
Identifiers
	IUPAC name 5-chloro-2-(2-(2-((3-(furan-3-yl)phenyl)amino)-2-oxoethoxy)acetamido)benzoic acid;
CAS Number	1190221-43-2;
PubChem CID	44250349;
ChemSpider	60598824;
UNII	33S35WFR9H;
ChEMBL	ChEMBL4204253;
E number	{{#property:P628}}
CompTox Dashboard (EPA)	{{#property:P3117}}Lua error in Module:EditAtWikidata at line 29: attempt to index field 'wikibase' (a nil value).;
ECHA InfoCard	{{#property:P2566}}Lua error in Module:EditAtWikidata at line 29: attempt to index field 'wikibase' (a nil value).
Chemical and physical data
Formula	C21H17ClN2O6
Molar mass	428.83 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES C1=CC(=CC(=C1)NC(=O)COCC(=O)NC2=C(C=C(C=C2)Cl)C(=O)O)C3=COC=C3;
	InChI InChI=1S/C21H17ClN2O6/c22-15-4-5-18(17(9-15)21(27)28)24-20(26)12-30-11-19(25)23-16-3-1-2-13(8-16)14-6-7-29-10-14/h1-10H,11-12H2,(H,23,25)(H,24,26)(H,27,28); Key:BGGMLMAPVODXAU-UHFFFAOYSA-N;

TM5441 is a drug which acts as an inhibitor of the serpin protein plasminogen activator inhibitor-1 (PAI-1). By inhibiting PAI-1, it increases activity of the enzymes tissue plasminogen activator and urokinase, which are involved in the blood clotting cascade. It has been researched for conditions such as hepatic steatosis and diabetic nephropathy, and while it has not been developed for medical use, it is widely used in scientific research.^[1]^[2]^[3]^[4]

References

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Clinical data

ATC code	None
Identifiers
IUPAC name 5-chloro-2-(2-(2-((3-(furan-3-yl)phenyl)amino)-2-oxoethoxy)acetamido)benzoic acid
CAS Number	1190221-43-2
PubChem CID	44250349
ChemSpider	60598824
UNII	33S35WFR9H
ChEMBL	ChEMBL4204253
E number	{{#property:P628}}
CompTox Dashboard (EPA)	{{#property:P3117}}Lua error in Module:EditAtWikidata at line 29: attempt to index field 'wikibase' (a nil value).
ECHA InfoCard	{{#property:P2566}}Lua error in Module:EditAtWikidata at line 29: attempt to index field 'wikibase' (a nil value).
Chemical and physical data
Formula	C₂₁H₁₇ClN₂O₆
Molar mass	428.83 g·mol⁻¹
3D model (JSmol)	Interactive image
SMILES C1=CC(=CC(=C1)NC(=O)COCC(=O)NC2=C(C=C(C=C2)Cl)C(=O)O)C3=COC=C3
InChI InChI=1S/C21H17ClN2O6/c22-15-4-5-18(17(9-15)21(27)28)24-20(26)12-30-11-19(25)23-16-3-1-2-13(8-16)14-6-7-29-10-14/h1-10H,11-12H2,(H,23,25)(H,24,26)(H,27,28) Key:BGGMLMAPVODXAU-UHFFFAOYSA-N