TFE3
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Lua error in Module:Infobox_gene at line 53: attempt to index field 'wikibase' (a nil value). Transcription factor E3 is a protein that in humans is encoded by the TFE3 gene.[1][2][3]
Function
[edit | edit source]TFE3, a member of the helix-loop-helix family of transcription factors, binds to the mu-E3 motif of the immunoglobulin heavy-chain enhancer and is expressed in many cell types (Henthorn et al., 1991).[supplied by OMIM][3]
Interactions
[edit | edit source]TFE3 has been shown to interact with:
- E2F3,[4]
- Microphthalmia-associated transcription factor,[5][6] and
- Mothers against decapentaplegic homolog 3[7][8]
Translocations
[edit | edit source]A proportion of renal carcinomas (RCC) that occur in young patients are associated with translocations involving the TFE3 gene at chromosome Xp11.2 PRCC[citation needed]
References
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Further reading
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