TFB1M
Lua error in Module:Infobox_gene at line 53: attempt to index field 'wikibase' (a nil value). Dimethyladenosine transferase 1, mitochondrial; Transcription factor B1, mitochondrial is a mitochondrial enzyme that is encoded by the TFB1M gene.[1][2][3]
TFB1M is a mitochondrial methyltransferase, which uses S-adenosyl methionine to dimethylate two highly conserved adenosine residues at the 3'-end of the mitochondrial 12S rRNA thereby regulating the assembly or stability of the small subunit of the mitochondrial ribosome.[2][4][5]
Additionally, TFB1M has been demonstrated to stimulate transcription from promoter templates in an in vitro system containing recombinant mitochondrial RNA polymerase and TFAM.[6] There are no experimental data demonstrating that this function occurs in vivo; the paralogous TFB2M is more specific for this role.[7]
Interactions
[edit | edit source]TFB1M has been shown to interact with TFAM.[8]
References
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Further reading
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