TEKTIP1

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TEKTIP1, also known as tektin-bundle interacting protein 1, is a protein that in humans is encoded by the TEKTIP1 gene.[1][2]

Gene

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Tektin bundle interacting protein 1 (TEKTIP1) is a protein which in humans is encoded by the TEKTIP1 mRNA.[1] The longest mRNA produced is 826 bases long.[3]

Aliases

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Alias of the protein is C19orf71.[4]

Locus

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The TEKTIP1 gene is located at 19p13.3.[5]

Transcriptional Regulation

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Several predicted transcription factors may bind in the promoter region: TFDP1, PLAGL1, ZSCAN4, POU2F3.[6][7][8][9][10]

Chemical Interactions

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Acrylamide,[11] cisplatin,[12] and silicon dioxide[13] decrease expression, while butanal (butyraldehyde), and pentanal increase expression[14] of TEKTIP1 mRNA.

Sequence orthology also suggests that valproic acid increases methylation of TEKTIP1 mRNA.[15]

Protein

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The mRNA of TEKTIP1 is 654 nucleotides long.[1][4] It contains five exons.[1] The human TEKTIP1 protein is 209 amino acids long and has a predicted molecular mass of 24.5 kDa.[4] The human protein has a theoretical isoelectric point of 9.1.[16]

Isoforms

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There are two splice isoforms of the protein, X1[17] and X2.[18]

X1 & X2 Isoform Orthologs
X1 X2
Tibetan macaque[19] Chimpanzee[20]
Olive baboon[21] Olive baboon[22]
Panamanian white-faced capuchin[23] Common marmoset[24]
Golden[25] and Black[26]

snub-nosed monkeys

Golden sub-nosed monkey[27]
Elk[28] Elk[29]
Red deer[30] Red deer[31]
Greater horseshoe bat[32] Bats[33][34][35]
Red fox[36] Polar bear[37]

Characteristics & structure

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TEKTIP1 is highly enriched in tryptophan and tyrosine.[38] Additionally, the protein is semi-enriched in arginine and proline.[39]

Expression

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TEKTIP1 is tissue specific and is found in higher levels in the kidney, testis and thymus.[5]

In fetal development, it is found in higher levels in the Adrenal glands during weeks 16-20.[5]

TEKTIP1 protein is said to be specific to the testis and is found in early spermatids during spermatogenesis.[40]

Evolution

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Orthologs

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Over 240 organisms have orthologs with human gene TEKTIP1.[5] The most distant organism with an orthologous sequence to human TEKTIP1 is the West African lungfish (estimated date of divergence of 408 MYA).[41][42]

Selected Orthologs for TEKTIP1
Genus and species Common name Taxonomic group Median Date of Divergence (MYA) Accession # Sequence length (aa) Sequence identity to human protein % Sequence similarity to Human Protein %
Homo sapiens Human Primates/Hominidae 0 NP_001129052.1 209 100 100
Pan troglodyte Chimpanzee Primates 6.4 XP_003316050.1 209 98.1 98.6
Mus musculus Mouse Rodentia 87 NP_001014836.2 217 45.6 60.4
Bos taurus Cow Artiodactyla 94 NP_001070550 208 76.6 84.2
Panthera tigris Tiger Carnivora 94 XP_042833719.1 210 34.1 38.9
Orcinus orca Killer whale Cetacea 94 XP_012394771.2 216 63 73.1
Phascolarctos cinereus Koala Diprodontia 160 XP_020824948.1 211 52.9 67.4
Haliaeetus leucocephalus Bald Eagle Accipitiformes 319 XP_010580112.1 206 41.4 52
Dromaius novaehollandiae Emu Aves 319 XP_025961204.1 190 44.8 56.7
Gallus gallus domesticus Chicken Aves 319 XP_015155269.2 188 38.2 48.4
Crocodylus porosus Saltwater Crocodile Crocodilia 319 XP_019406144.1 210 54.3 68.3
Caretta caretta Loggerhead Sea Turtle Testudines 319 XP_048687032.1 216 47.8 57.3
Zootoca vivipara Common lizard Squamata 319 XP_034975173.1 200 48.8 59.5
Crotalus tigris Tiger Rattlesnake Squamata 319 XP_039190693.1 199 45.8 57.5
Protobothrops mucrosquamatus Venomous Pit Viper Squamata 319 XP_015665555.1 199 45.1 56.7
Bufo bufo Common Toad Salientia 353 XP_040276375 136 24.7 34.3
Geotrypetes seraphini Gaboon Caecilian Caecilians 353 XP_033813379.1 156 36.1 45.8
Microcaecilia unicolor Tiny Caecilian Caecilians 353 XP_030074922.1 142 34.3 42.6
Protopterus annectens West African Lungfish Actinopterygii 408 XP_043910031.1 142 28.6 39

References

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  1. ^ a b c d Lua error in Module:Citation/CS1/Configuration at line 2172: attempt to index field '?' (a nil value).
  2. ^ GeneCard for C19orf71
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