T98G
T98G is a glioblastoma cell line used in brain cancer research and drug development.[1][2]
The T98G cell line was derived from a 61-year-old human male and has a hyper pentaploid chromosome count with a modal number ranging from 128 to 132. The cells are not tumorigenic in mice but do proliferate with proper anchorage in cell culture.[1] T98G cells are known for having high expression of the ACTA2 gene, which is involved in cell motility and structure.[3] T98G cells are polyploidy variants of the parent T98 cell line, and can stay in the G1 phase of the cell cycle under stationary conditions.[1]
T98G cells have been investigated along with A172 cells for drug cytotoxicity,[3] and were found to be resistant to cisplatin, with larger cytotoxic effects induced by viral-mediated production of the p53 protein.[4]
References
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