Streptogramin
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Streptogramins are a class of antibiotics. They work as protein synthesis inhibitors.[1]
Streptogramins are effective in the treatment of vancomycin-resistant Staphylococcus aureus (VRSA) and vancomycin-resistant Enterococcus (VRE), two of the most rapidly growing strains of multidrug-resistant bacteria. They fall into two groups: streptogramin A (23-membered macrolide) and streptogramin B (depsipeptide). The two groups act synergistically. They are naturally produced in a 3:7 ratio; most formulations keep this ratio.[2]
Members include:
- Quinupristin/dalfopristin, made by chemically modifying pristinamycin (semisynthesis)
- Pristinamycin, made by Streptomyces pristinaespiralis
- Virginiamycin, made by Streptomyces virginiae and others
- Linopristin/flopristin, made by semisynthesis. experimental streptogramin in clinical trials for the treatment of respiratory tract infections.[3]
- Etamycin, a streptogramin B.[4]
References
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Further reading
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