Stephania

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Stephania
File:Stephania cephalantha 玉咲葛藤 (天問) 001.jpg
Stephania cephalantha
Scientific classification Edit this classification
Kingdom: Plantae
Clade: Tracheophytes
Clade: Angiosperms
Clade: Eudicots
Order: Ranunculales
Family: Menispermaceae
Subfamily: Menispermoideae
Genus: Stephania
Lour.
Synonyms[1]
  • Miers Noronha
  • Miers Clypea
  • Byrsa Blume
  • Homocnemia Ileocarpus

Stephania is a genus of flowering plants in the family Menispermaceae. It includes 70 species native to tropical and southern Africa, eastern and southern Asia, Australia, and the tropical Pacific Islands.[1][2] They are herbaceous perennial vines, growing to around four metres tall, with a large tuber. The leaves are arranged spirally on the stem and are peltate, with the leaf petiole attached near the centre of the leaf. The name Stephania comes from the Greek, "a crown". This refers to the anthers being arranged in a crown-like manner.[3]

One species, S. tetrandra, is among the 50 fundamental herbs used in traditional Chinese medicine, where it is called han fang ji (漢防己, "Chinese fang ji"). Other plants named fang ji are sometimes substituted for it. Other varieties substituted include Cocculus thunbergii, C. trulobus, Aristolochia fangchi, Stephania tetrandria, and Sinomenium acutum. Notable among these is guang fang ji (廣防己, "(GuangDong, GuangXi) fang ji", Aristolochia fangchi. Because of its toxicity, it is used in TCM only with great caution.

Species

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70 species are accepted.[1][4][5]

Fossil species
Formerly placed here

Toxicity

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File:Stephania-delavayi Menispermaceae flowers.jpg
Female flowers of Stephania delavayi

There is evidence that a few species of Stephania are toxic.[7] However, the most commonly available species in the United States, Stephania tetrandra, has not been shown to be toxic. Any confusion regarding the possible toxicity of Stephania tetrandra was entirely due to an inadvertent shipment of Aristolochia fangchi sent in its stead to a Belgian clinic in 1993. The errant batch of Aristolochia was later confirmed via phytochemical analysis.[8]

Chemistry

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Chemical investigation of Stephania rotunda Lour. growing in Vietnam in 2005 led to the isolation and structural elucidation of three new alkaloids, 5-hydroxy-6,7-dimethoxy-3,4-dihydroisoquinolin-1(2H)-one, thaicanine 4-O-beta-D-glucoside, as well as (−)-thaicanine N-oxide (4-hydroxycorynoxidine), along with 23 known alkaloids.[9]

References

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  7. ^ [1] Journal of Ethnopharmacology 132 (2010). p. 380
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