Sorbinil

Sorbinil
	Structural formula of sorbinil
	Ball-and-stick model of the sorbinil molecule
Names
	Preferred IUPAC name (4S)-6-Fluoro-2,3-dihydrospiro[[1]benzopyran-4,4′-imidazolidine]-2,5-dione
	Other names (S)-6-Fluorospiro(chroman-4,4'-imidazolidine)-2',5'-dione; CP 45634
Identifiers
CAS Number	68367-52-2;
3D model (JSmol)	Interactive image;
ChEMBL	ChEMBL7681;
ChemSpider	298991;
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E number	Lua error in Module:Wikidata at line 880: attempt to index field 'wikibase' (a nil value).
IUPHAR/BPS	7415;
KEGG	D05893;
PubChem CID	337359;
UNII	G4186B906P check;
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	InChI InChI=1S/C11H9FN2O3/c12-6-1-2-8-7(5-6)11(3-4-17-8)9(15)13-10(16)14-11/h1-2,5H,3-4H2,(H2,13,14,15,16)/t11-/m0/s1;
	SMILES Fc3ccc2OCC[C@@]1(C(=O)NC(=O)N1)c2c3;
Properties
Chemical formula	C11H9FN2O3
Molar mass	236.202 g·mol−1
Appearance	White to off-white powder
	Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). Infobox references

Sorbinil (INN) is an aldose reductase inhibitor being investigated for treatment of diabetic complications including neuropathy and retinopathy.^[3] Aldose reductase is an enzyme present in lens and brain that removes excess glucose by converting it to sorbitol. Sorbitol accumulation can lead to the development of cataracts in the lens and neuropathy in peripheral nerves. Sorbinil has been shown to inhibit aldose reductase in human brain^[4] and placenta^[5] and calf^[6] and rat lens.^[5] Sorbinil reduced sorbitol accumulation in rat lens and sciatic nerve of diabetic rats orally administered 0.25 mg/kg sorbinil.^[5]

References

^ Sorbinil at Sigma-Aldrich
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