STARD13
Lua error in Module:Infobox_gene at line 53: attempt to index field 'wikibase' (a nil value). StAR-related lipid transfer domain protein 13 (STARD13) also known as deleted in liver cancer 2 protein (DLC-2) is a protein that in humans is encoded by the STARD13 gene and a member of the DLC family of proteins.[1][2]
Function and structure
[edit | edit source]STARD13 serves as a Rho GTPase-activating protein (GAP), a type of protein that regulates members of the Rho family of GTPases.[3] It selectively activates RhoA and CDC42 and suppresses cell growth by inhibiting actin stress fiber assembly.[3]
The protein consists of an N-terminal sterile alpha motif (SAM) domain,[4] a serine-rich domain, a RhoGAP domain and at the C-terminus, a StAR-related lipid-transfer domain (START).
Tissue distribution and pathology
[edit | edit source]The protein was identified in part through its differential expression in cancers. A low level of STARD13 was observed in less differentiated hepatocellular carcinoma tissue with higher RhoA expression. A small patient study finds that the absence of STARD13 in hepatocellular carcinomas correlates with higher levels of RhoA and a poorer prognosis than patients with carcinomas that were STARD13-positive.[5]
References
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Further reading
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