SPEF2
Lua error in Module:Infobox_gene at line 53: attempt to index field 'wikibase' (a nil value). Sperm flagellar protein 2 is a protein that in humans is encoded by the SPEF2 gene.[1][2][3][4]
SPEF2 plays an important role in spermatogenesis and flagellar assembly.[5] SPEF2 is expressed in all ciliated cells and is required for cilia function.[5][6] Sperm contain cilia, and a mutation in the SPEF2 gene can cause male infertility due to immobile sperm.[5][6] In a pig animal model, a SPEF2 mutation affects the sperm tail development.[6] And a loss of function mutation in SPEF2 in mice causes the big giant head phenotype.[5] SPEF2 mRNA and protein products are localized in germ and sertoli cells.[6] Within these cells, SPEF2 is localized in the golgi complex, manchette, basal body and mid piece of the sperm tail.[6] SPEF2 has been shown to interact with the intracellular transport protein IFT20 in the testis.[6]
References
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Further reading
[edit | edit source]- Lua error in Module:Citation/CS1/Configuration at line 2172: attempt to index field '?' (a nil value).
- Lua error in Module:Citation/CS1/Configuration at line 2172: attempt to index field '?' (a nil value).
- Lua error in Module:Citation/CS1/Configuration at line 2172: attempt to index field '?' (a nil value).
