SOS box
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SOS box is the operator to which the LexA repressor binds to repress the transcription of SOS-induced proteins. SOS boxes are found near the promoter of various genes.[1]
LexA binds to an SOS box in the absence of DNA damage. In the presence of DNA damage the binding of LexA is inactivated by the RecA activator. SOS boxes differ in DNA sequences and binding affinity towards LexA from organism to organism.[2] Furthermore, SOS boxes may be present in a dual fashion, which indicates that more than one SOS box can be within the same promoter.[3]
Examples
[edit | edit source]| Phylogenetic Clade | Sequence | Reference |
|---|---|---|
| Alphaproteobacteria | GAAC(N)7GAAC GTTC(N)7GTTC |
[4][5] |
| Betaproteobacteria Gammaproteobacteria |
CTGT(N)8ACAG | [6] |
| Deltaproteobacteria | CTRHAMRYBYGTTCAGS | [7] |
| Gram-positive bacteria | CGAACRNRYGTTYC | [8][9] |
| Cyanobacteria | RGTAC(N)3DGTWCB | [10] |
See Nucleic acid nomenclature for an explanation of non-GATC nucleotide letters.
See also
[edit | edit source]References
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