SOSTDC1
Lua error in Module:Infobox_gene at line 53: attempt to index field 'wikibase' (a nil value). Sclerostin domain-containing protein 1 is a protein that in humans is encoded by the SOSTDC1 gene.[1]
Function
[edit | edit source]This gene is a member of the sclerostin family and encodes Uterine sensitization-associated gene-1 (USAG-1), an N-glycosylated, secreted protein with a C-terminal, cystine, knot-like domain. This protein functions as a bone morphogenetic protein (BMP) antagonist. Specifically, it directly associates with BMPs, prohibiting them from binding their receptors, thereby regulating BMP signaling during cellular proliferation, differentiation, and programmed cell death.[1]
Inhibition of USAG-1 is of interest as a potential means of stimulating tooth regeneration for dentistry.[2][3][4]
References
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Further reading
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