SNAP-7941

SNAP-7941
	File:SNAP-7941 structure.png
Identifiers
CAS Number	387825-78-7 ☒[EPA];
PubChem CID	11520239;
ChemSpider	9695027;
ChEMBL	ChEMBL185271 ☒;
E number	{{#property:P628}}
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ECHA InfoCard	{{#property:P2566}}Lua error in Module:EditAtWikidata at line 29: attempt to index field 'wikibase' (a nil value).
Chemical and physical data
Formula	C33H41F2N5O6
Molar mass	641.717 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES CC(C)C(=O)Nc(c4)cccc4C3CCN(CC3)CCCNC(=O)N(C(=O)NC=1COC)C(C=1C(=O)OC)c(cc2F)ccc2F;
	InChI InChI=1S/C31H37F2N5O6/c1-19(39)35-23-7-4-6-21(16-23)20-10-14-37(15-11-20)13-5-12-34-30(41)38-28(22-8-9-24(32)25(33)17-22)27(29(40)44-3)26(18-43-2)36-31(38)42/h4,6-9,16-17,20,28H,5,10-15,18H2,1-3H3,(H,34,41)(H,35,39)(H,36,42)/t28-/m0/s1; Key:FWMHZWMPUWAUPL-NDEPHWFRSA-N;
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SNAP-7941 is a drug used in scientific research, which is a selective, non-peptide antagonist at the melanin concentrating hormone receptor MCH₁. In initial animal studies it had promising anxiolytic, antidepressant and anorectic effects,^[1]^[2] but subsequent trial results were disappointing,^[3] and the main significance of SNAP-7941 is as the lead compound from which more potent and selective antagonists such as SNAP-94847 were developed,^[4]^[5] although it continues to be used for research into the function of the MCH₁ receptor.^[6]^[7]

References

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v t e Melanocortin receptor modulators
MC₁	Agonists: ACTH (corticotropin) Afamelanotide (melanotan I) BMS-470539 Bremelanotide HS-014 HS-024 MSH (α, β, γ) Melanotan II Modimelanotide PL-8177 SHU-8914 SHU-9005 SHU-9119 SNAP-7941 Antagonists: ASIP
MC₂	Agonists: ACTH (corticotropin) Alsactide Codactide Giractide Norleusactide (pentacosactride) Seractide Tetracosactide (tetracosactrin, cosyntropin) Tosactide (octacosactrin) Tricosactide Tridecactide Antagonists: Atumelnant (CRN04894)
MC₃	Agonists: ACTH (corticotropin) Afamelanotide (melanotan I) Bremelanotide MSH (α, β, γ) Melanotan II Modimelanotide PG-931 Antagonists: AGRP ASIP HS-014 Mifomelatide (TCMCB07) ML-00253764 PG-106 SHU-8914 SHU-9005 SHU-9119
MC₄	Agonists: ACTH (corticotropin) Afamelanotide (melanotan I) AZD2820 BIM-22493 Bivamelagon (LB54640) Bremelanotide LY-2112688 MSH (α, β, γ) Melanotan II MK-0493 Modimelanotide PF-00446687 PG-931 PL-6983 Ro 27-3225 Setmelanotide THIQ Antagonists: AGRP ASIP HS-014 HS-024 HS-131 JKC-363 MCL-0020 MCL-0042 MCL-0129 ML-00253764 MPB-10 SHU-8914 SHU-9005 SHU-9119 Unknown: Semax
MC₅	Agonists: ACTH (corticotropin) Afamelanotide (melanotan I) Bremelanotide HS-014 HS-024 MSH (α, β, γ) Melanotan II Modimelanotide SHU-8914 SHU-9005 SHU-9119 Antagonists: ASIP ML-00253764 Unknown: Semax
Unsorted	Agonists: Alsactide Codactide Dersimelagon Giractide Norleusactide (pentacosactride) Seractide Tetracosactide (tetracosactrin, cosyntropin) Tosactide (octacosactrin) Tricosactide Tridecactide
Others	Propeptides: Lipotropin (β, γ) N-POMC (NPP, pro-γ-MSH) Proopiomelanocortin (POMC)

Identifiers
File:SNAP-7941 structure.png
CAS Number	387825-78-7^☒N[EPA]
PubChem CID	11520239
ChemSpider	9695027
ChEMBL	ChEMBL185271^☒N
E number	{{#property:P628}}
CompTox Dashboard (EPA)	{{#property:P3117}}Lua error in Module:EditAtWikidata at line 29: attempt to index field 'wikibase' (a nil value).
ECHA InfoCard	{{#property:P2566}}Lua error in Module:EditAtWikidata at line 29: attempt to index field 'wikibase' (a nil value).
Chemical and physical data
Formula	C₃₃H₄₁F₂N₅O₆
Molar mass	641.717 g·mol⁻¹
3D model (JSmol)	Interactive image
SMILES CC(C)C(=O)Nc(c4)cccc4C3CCN(CC3)CCCNC(=O)N(C(=O)NC=1COC)C(C=1C(=O)OC)c(cc2F)ccc2F
InChI InChI=1S/C31H37F2N5O6/c1-19(39)35-23-7-4-6-21(16-23)20-10-14-37(15-11-20)13-5-12-34-30(41)38-28(22-8-9-24(32)25(33)17-22)27(29(40)44-3)26(18-43-2)36-31(38)42/h4,6-9,16-17,20,28H,5,10-15,18H2,1-3H3,(H,34,41)(H,35,39)(H,36,42)/t28-/m0/s1 Key:FWMHZWMPUWAUPL-NDEPHWFRSA-N
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SNAP-7941

References

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