SMARCE1
Lua error in Module:Infobox_gene at line 53: attempt to index field 'wikibase' (a nil value). SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1 is a protein that in humans is encoded by the SMARCE1 gene.[1][2]
Function
[edit | edit source]The protein encoded by this gene is part of the large ATP-dependent chromatin remodeling complex SWI/SNF, which is required for transcriptional activation of genes normally repressed by chromatin. The encoded protein, either alone or when in the SWI/SNF complex, can bind to 4-way junction DNA, which is thought to mimic the topology of DNA as it enters or exits the nucleosome. The protein contains a DNA-binding HMG domain, but disruption of this domain does not abolish the DNA-binding or nucleosome-displacement activities of the SWI/SNF complex. Unlike most of the SWI/SNF complex proteins, this protein has no yeast counterpart.[2]
Interactions
[edit | edit source]SMARCE1 has been shown to interact with Estrogen receptor alpha,[3] SMARCB1[4][5] and SMARCA4.[4][5]
References
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Further reading
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