GLUT5
Lua error in Module:Infobox_gene at line 53: attempt to index field 'wikibase' (a nil value). GLUT5 is a fructose transporter expressed on the apical border of enterocytes in the small intestine.[1] GLUT5 allows for fructose to be transported from the intestinal lumen into the enterocyte by facilitated diffusion due to fructose's high concentration in the intestinal lumen. GLUT5 is also expressed in skeletal muscle,[2] testis, kidney, fat tissue (adipocytes), and brain.[3]
Fructose malabsorption or Dietary Fructose Intolerance is a dietary disability of the small intestine, where the amount of fructose carrier in enterocytes is deficient.[4]
In humans the GLUT5 protein is encoded by the SLC2A5 gene.[5]
Regulation
[edit | edit source]Fructose uptake rate by GLUT5 is significantly reduced by diabetes mellitus, hypertension, obesity, fructose malabsorption, and inflammation. However, age-related changes in fructose intake capability are not explained by the rate of expression of GLUT5.[6][7][8] The absorption of fructose in the simultaneous presence of glucose is improved, while sorbitol is inhibitory.[9] Fructose absorption by GLUT5 can be investigated using intestinal organoids.[10][11]
Interactive pathway map
[edit | edit source]Click on genes, proteins and metabolites below to link to respective articles.[§ 1]
- ^ The interactive pathway map can be edited at WikiPathways: Lua error in Module:Citation/CS1/Configuration at line 2172: attempt to index field '?' (a nil value).
References
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- ^ Heinrich Kasper: Ernährungsmedizin und Diätetik. 11. Auflage, Elsevier, Urban&Fischer-Verlag, 2009, Lua error in Module:Citation/CS1/Configuration at line 2172: attempt to index field '?' (a nil value)., S. 208
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External links
[edit | edit source]- GLUT5+Protein at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
