SH3RF1
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Lua error in Module:Infobox_gene at line 53: attempt to index field 'wikibase' (a nil value). Putative E3 ubiquitin-protein ligase SH3RF1 is an enzyme that in humans is encoded by the SH3RF1 gene.[1][2]
Function
[edit | edit source]This gene encodes a protein containing an N-terminus RING-finger, four SH3 domains, and a region implicated in binding of the Rho GTPase Rac. Via the RING-finger, the encoded protein has been shown to function as a ubiquitin-protein ligase involved in protein sorting at the trans-Golgi network. The encoded protein may also act as a scaffold for the c-Jun N-terminal kinase signaling pathway, facilitating the formation of a functional signaling module.[2]
Interactions
[edit | edit source]SH3RF1 has been shown to interact with AKT2[3] and MAP3K11.[3]
References
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Further reading
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