SH2B2
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Lua error in Module:Infobox_gene at line 53: attempt to index field 'wikibase' (a nil value). SH2B adapter protein 2 is a protein that in humans is encoded by the SH2B2 gene.[1][2]
Function
[edit | edit source]The protein encoded by this gene is expressed in B lymphocytes and contains pleckstrin homology and src homology 2 (SH2) domains. In Burkitt lymphoma cell lines, it is tyrosine phosphorylated in response to B cell receptor stimulation. Because it binds Shc independent of stimulation and Grb2 after stimulation, it appears to play a role in signal transduction from the receptor to Shc/Grb2.[2]
Interactions
[edit | edit source]SH2B2 has been shown to interact with TrkA[3] and Cbl gene.[4][5]
References
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Further reading
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