SESN3
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Sestrin 3 is a protein that in humans is encoded by the SESN3 gene. [1]
Function
[edit | edit source]This gene encodes a member of the sestrin family of stress-induced proteins. The encoded protein reduces the levels of intracellular reactive oxygen species induced by activated Ras downstream of RAC-alpha serine/threonine-protein kinase (Akt) and FoxO transcription factor. The protein is required for normal regulation of blood glucose, insulin resistance and plays a role in lipid storage in obesity. Alternative splicing results in multiple transcript variants.
References
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Further reading
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This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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