SERPINB9
Lua error in Module:Infobox_gene at line 53: attempt to index field 'wikibase' (a nil value). Serpin B9 is a protein that in humans is encoded by the SERPINB9 gene.[1][2][3] Serpin B9 is an inhibitor of Granzyme B (GzmB). GzmB is a potent cytotoxic molecule that is secreted by cytotoxic T lymphocytes and natural killer (NK) cells to induce apoptosis in target cells during an immune response. Serpin B9, expressed in the cytosol and nucleus, thus protects from apoptosis by cytotoxic T lymphocytes and NK cells.[4]
Serpin B9 belongs to the large superfamily of serine proteinase inhibitors (serpins), which bind to and inactivate serine proteinases. These interactions are involved in many cellular processes, including coagulation, fibrinolysis, complement fixation, matrix remodeling, and apoptosis (Sprecher et al., 1995).[supplied by OMIM][3]
See also
[edit | edit source]References
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Further reading
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External links
[edit | edit source]- The MEROPS online database for peptidases and their inhibitors: I04.014[permanent dead link]
- SERPINB9+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
