SEPT6
Lua error in Module:Infobox_gene at line 53: attempt to index field 'wikibase' (a nil value). Septin-6 is a protein that in humans is encoded by the SEPT6 gene.[1][2][3]
Function
[edit | edit source]This gene is a member of the septin family of GTPases. Members of this family are required for cytokinesis. This gene encodes four transcript variants encoding three distinct isoforms. An additional transcript variant has been identified, but its biological validity has not been determined.[3]
Clinical significance
[edit | edit source]One version of pediatric acute myeloid leukemia is the result of a reciprocal translocation between chromosomes 11 and X, with the breakpoint associated with the genes encoding the mixed-lineage leukemia and septin 2 proteins.[3]
Interactions
[edit | edit source]SEPT6 has been shown to interact with SEPT2.[4][5]
References
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Further reading
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