SEMA4A
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Lua error in Module:Infobox_gene at line 53: attempt to index field 'wikibase' (a nil value). Semaphorin-4A is a protein that in humans is encoded by the SEMA4A gene.[1][2]
Function
[edit | edit source]SEMA4A is a member of the semaphorin family of soluble and transmembrane proteins. Semaphorins are involved in guidance of axonal migration during neuronal development and in immune responses.[supplied by OMIM][2]
Clinical significance
[edit | edit source]A germline variant in SEMA4A (V78M) has been demonstrated to confer risk for colorectal cancer type X.[3]
Recently it has been identified as a novel therapeutic target in Multiple myeloma.[4]
References
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Further reading
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