Rebecsinib

Rebecsinib
	File:Rebecsinib structure.png
Identifiers
	IUPAC name (2S,3S,6S,7R,10S,E)-7,10-dihydroxy-2-((2E,4E,6R,7S)-7-hydroxy-7-((2R,3R)-3-((2R,3S)-3-methoxypentan-2-yl)oxiran-2-yl)-6-methylhepta-2,4-dien-2-yl)-3,7-dimethyl-12-oxooxacyclododec-4-en-6-yl acetate;
CAS Number	2598242-04-5;
PubChem CID	9915974;
ChemSpider	8091622;
ChEBI	CHEBI:226528;
E number	{{#property:P628}}
CompTox Dashboard (EPA)	{{#property:P3117}}Lua error in Module:EditAtWikidata at line 29: attempt to index field 'wikibase' (a nil value).;
ECHA InfoCard	{{#property:P2566}}Lua error in Module:EditAtWikidata at line 29: attempt to index field 'wikibase' (a nil value).
Chemical and physical data
Formula	C31H50O9
Molar mass	566.732 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES CO[C@@H](CC)[C@@H](C)[C@H]1O[C@@H]1[C@@H](O)[C@H](C)\C=C\C=C(/C)[C@@H]1OC(=O)C[C@H](O)CC[C@@](C)(O)[C@@H](OC(C)=O)\C=C\[C@@H]1C;
	InChI InChI=1S/C31H50O9/c1-9-24(37-8)21(5)29-30(40-29)27(35)18(2)11-10-12-19(3)28-20(4)13-14-25(38-22(6)32)31(7,36)16-15-23(33)17-26(34)39-28/h10-14,18,20-21,23-25,27-30,33,35-36H,9,15-17H2,1-8H3/b11-10+,14-13+,19-12+; Key:LDCZLUDGHYDTHV-FPZDJJGISA-N;

Rebecsinib (17S-FD-895) is an experimental anticancer medication derived by modification of the natural product Pladienolide B, which acts as an inhibitor of splicing-mediated activation of the enzyme ADAR1, and is in development as a potential treatment for leukemia.^[1]^[2]^[3]^[4]^[5]

References

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Rebecsinib

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Identifiers
File:Rebecsinib structure.png
IUPAC name (2S,3S,6S,7R,10S,E)-7,10-dihydroxy-2-((2E,4E,6R,7S)-7-hydroxy-7-((2R,3R)-3-((2R,3S)-3-methoxypentan-2-yl)oxiran-2-yl)-6-methylhepta-2,4-dien-2-yl)-3,7-dimethyl-12-oxooxacyclododec-4-en-6-yl acetate
CAS Number	2598242-04-5
PubChem CID	9915974
ChemSpider	8091622
ChEBI	CHEBI:226528
E number	{{#property:P628}}
CompTox Dashboard (EPA)	{{#property:P3117}}Lua error in Module:EditAtWikidata at line 29: attempt to index field 'wikibase' (a nil value).
ECHA InfoCard	{{#property:P2566}}Lua error in Module:EditAtWikidata at line 29: attempt to index field 'wikibase' (a nil value).
Chemical and physical data
Formula	C₃₁H₅₀O₉
Molar mass	566.732 g·mol⁻¹
3D model (JSmol)	Interactive image
SMILES CO[C@@H](CC)[C@@H](C)[C@H]1O[C@@H]1[C@@H](O)[C@H](C)\C=C\C=C(/C)[C@@H]1OC(=O)C[C@H](O)CC[C@@](C)(O)[C@@H](OC(C)=O)\C=C\[C@@H]1C
InChI InChI=1S/C31H50O9/c1-9-24(37-8)21(5)29-30(40-29)27(35)18(2)11-10-12-19(3)28-20(4)13-14-25(38-22(6)32)31(7,36)16-15-23(33)17-26(34)39-28/h10-14,18,20-21,23-25,27-30,33,35-36H,9,15-17H2,1-8H3/b11-10+,14-13+,19-12+ Key:LDCZLUDGHYDTHV-FPZDJJGISA-N

Rebecsinib

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