RTCB
Lua error in Module:Infobox_gene at line 53: attempt to index field 'wikibase' (a nil value). RNA 2',3'-cyclic phosphate and 5'-OH ligase is a protein that in humans is encoded by the RTCB gene.[1] It is found in the stress granule of cells.[2]
Structure
[edit | edit source]As of June 2019[update], no crystal structure of the human RTCB is known, but homology models built from other RtcB-family ligases are available (Swiss-model: Q9Y3I0). The structure of Pyrococcus horikoshii RtcB, which uses GTP instead of ATP, shows two manganese (Mn2+) cofactors, and a mechanism involving a covalently linked GTP-histidine-RtcB intermediate. The residue involved, H404, is conserved in human RTCB as H428.[3]
Function
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Protein family
[edit | edit source]| tRNA splicing ligase RtcB | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| Symbol | RtcB | ||||||||
| Pfam | PF01139 | ||||||||
| InterPro | IPR001233 | ||||||||
| PROSITE | PS01288 | ||||||||
| CATH | 1uc2 | ||||||||
| SCOP2 | 1uc2 / SCOPe / SUPFAM | ||||||||
| |||||||||
RTCB belongs to the RtcB family of ATP-dependent RNA ligases, named after the eponymous protein in E. coli. The bacterial RtcB acts as a tRNA ligase, rejoining broken stem-loops in case of damage.[4] It is also able to catalyse RNA splicing.[5]
The eukaryotic homologs of RtcB, including the human RTCB protein, participates in the tRNA-splicing ligase complex.[6]
References
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Further reading
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External links
[edit | edit source]- MetaCyc: CPLX-9136: Homo sapiens tRNA-splicing ligase complex (GO:0072669)
