mRNA (guanine-N7-)-methyltransferase
| mRNA (guanine-N7-)-methyltransferase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 2.1.1.56 | ||||||||
| CAS no. | 56941-25-4 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
Lua error in Module:Infobox_gene at line 53: attempt to index field 'wikibase' (a nil value). In enzymology, a mRNA (guanine-N7-)-methyltransferase also known as mRNA cap guanine-N7 methyltransferase is an enzyme that catalyzes the chemical reaction
- S-adenosyl-L-methionine + G(5')pppR-RNA S-adenosyl-L-homocysteine + m7G(5')pppR-RNA (mRNA containing an N7-methylguanine cap)
Thus, the two substrates of this enzyme are S-adenosyl methionine and G(5')pppR-RNA, whereas its two products are S-adenosylhomocysteine and m7G(5')pppR-RNA. This enzyme belongs to the family of transferases, specifically those transferring one-carbon group methyltransferases.
In humans, mRNA cap guanine-N7 methyltransferase is encoded by the RNMT gene.[1][2][3]
Nomenclature
[edit | edit source]The systematic name of this enzyme class is S-adenosyl-L-methionine:mRNA (guanine-N7-)-methyltransferase. Other names in common use include:
- messenger ribonucleate guanine 7-methyltransferase,
- guanine-7-methyltransferase,
- messenger RNA guanine 7-methyltransferase, and
- S-adenosyl-L-methionine:mRNA (guanine-7-N-)-methyltransferase.
- cap MTase
See also
[edit | edit source]References
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Further reading
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